Pick Disease of the Brain

A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)

Also Known As:

Pick's Disease; Brain Atrophy, Circumscribed Lobar; Dementia with Lobar Atrophy and Neuronal Cytoplasmic Inclusions; Lobar Atrophy Of Brain; Pick Disease; Pick Disease Of Brain; Picks Disease of Brain; Atrophies, Lobar (Brain); Atrophy, Lobar (Brain); Disease, Pick; Disease, Pick's; Lobar Atrophies (Brain); Picks Disease; Circumscribed Lobar Atrophy of the Brain; Lobar Atrophy (Brain); Lobar Atrophy of the Brain

Nervous System Diseases: 14178
- Central Nervous System Diseases: 4213
  - Brain Diseases: 15694
    - Dementia: 38184
      - Frontotemporal Lobar Degeneration: 1673
        Frontotemporal Dementia: 2707
        Pick Disease of the Brain: 388
Mental Disorders: 24177
- Neurocognitive Disorders: 1448
  - Dementia: 38184
    - Frontotemporal Lobar Degeneration: 1673
      - Frontotemporal Dementia: 2707
        Pick Disease of the Brain: 388

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